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desvenlafaxine will raise the amount or outcome of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Keep track of. Desvenlafaxine inhibits CYP2D6; with greater desvenlafaxine doses (ie, 400 mg) reduce the CYP2D6 substrate dose by up to 50%; no dosage adjustment necessary with desvenlafaxine doses seven consecutive days right awa